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Clinical Laboratory Quantitative Drug Testing Services

Laboratory Technology

Realize the Benefits of Dominion’s Optimum Combination of Testing Methodologies

Laboratory Technology and Testing Methodologies

Leveraging Innovative Technologies to Provide Unparalleled Quality and Accuracy

Rely upon the latest, most sensitive and specific assays to provide quantitative results you can count on. We employ the optimum combination of Ultra Performance Liquid Chromatography/Tandem Mass Spectrometry (UPLC/MS/MS), Gas Chromatography/Mass Spectrometry (GC/MS) and Enzyme Immunoassay (EIA) to provide you the highest level of accuracy in the industry.

LCMSMS Analyzer

UPLC/MS/MS analyzer

Ultra Performance Liquid Chromatography/Tandem Mass Spectrometry (UPLC/MS/MS)

Dominion was the first laboratory specializing in Pain and Addiction Medicine to use UPLC/MS/MS technology. Dominion uses UPLC/MS/MS, the highest analytical standard in the industry, for both initial profiles and confirmatory procedures to provide many test advantages including increased throughput, historically low levels of quantification, specificity and speed. The accurate, objective data reported through UPLC/MS/MS technology gives you key information for making informed clinical decisions for your patients.

UPLC/MS/MS Technical Summary

UPLC/MS/MS is used for the molecular identification and quantification of specific drug compounds. In UPLC/MS/MS, a liquid chromatograph (LC) is connected to a two-stage mass spectrometer. Separation of the drugs occurs in the liquid chromatograph as the compounds travel through the column. As the injected sample elutes from the column, the drugs are ionized. In the first stage of mass spectrometry, drug ions of interest are isolated. Those selected ions move on to the second stage of mass spectrometry where a unique “drug fingerprint” is produced which is characteristic of that specific drug only.

GCMS Analyzer

GC/MS analyzer

Gas Chromatography/Mass Spectrometry (GC/MS)

When the higher sensitivity and specificity of UPLC/MS/MS is not required, Dominion turns to GC/MS to confirm detected medications and illicit substances in your patient’s initial testing profile. GC/MS provides quantitative confirmation of drugs present and offers specific compound identification to differentiate between common analytes in a drug class.

GC/MS Technical Summary

GC/MS is used for the molecular identification of specific drug compounds. In GC/MS, a gas chromatograph is connected to a mass spectrometer. The sample is injected into the GC and is swept down a column (stationary phase) by a stream of inert gas. Separation of the drugs occurs in the gas chromatograph as the compounds travel through the column. As the drugs elute from the column, they pass into the mass spectrometer and are exposed to a beam of electrons. The ionized fragments are characteristic of a specific molecule and produce a unique “drug fingerprint” which is characteristic of that specific drug only.

EIA Analyzer

EIA analyzer

Enzyme Immunoassay (EIA)

For many initial testing profiles, Dominion relies upon cloned enzyme immunoassay (EIA) technology for quantitative detection of medications and illicit substances. Dominion’s quantitative EIA technology has been clinically validated as per the College of American Pathologists (CAP). Through the use of cloned analyte-specific enzyme donors, EIA offers consistent reproducibility of results and, in turn, enhanced accuracy and reliability.

EIA Technical Summary

EIA, used for the initial test in the testing process, is typically designed to detect the presence of multiple drugs and /or drug metabolites. The EIA technology involves a specialized enzyme mixed with analyte-specific antibodies. If analyte (drug) is present in the specimen, an active enzyme will form generating a color change that can be measured on a spectrophotometric analyzer. The amount of enzyme formed is proportional to the amount of analyte present in the specimen.

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